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Livers from patients, who overdosed on acetaminophen, exhibit upregulation of ABCC1 and ABCC4 mRNAs and elevated protein levels of ABCB1, ABCG2, ABCC4 and ABCC5

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Metabolism was terminated by adding acetonitrile, and the samples were analyzed by HPLC/MS

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One theory is that mental health problems are caused by high homocysteine levels (vitamin B12 is needed to break down this chemical)